Development of a Grp94 inhibitor

Heat shock protein 90 (Hsp90) represents a promising therapeutic target for the treatment of cancer and other diseases. Unfortunately, results from clinical trials have been disappointing as off-target effects and toxicities have been observed. These detriments may be a consequence of pan-Hsp90 inhi...

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Main Authors: Duerfeldt, Adam S., Peterson, Laura B., Maynard, Jason C., Ng, Chun Leung, Eletto, Davide, Ostrovsky, Olga, Shinogle, Heather E., Moore, David S., Argon, Yair, Nicchitta, Christopher V., Blagg, Brian S. J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414055/
https://ncbi.nlm.nih.gov/pubmed/22642269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja303477g
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