Toggled RNA Aptamers Against Aminoglycosides Allowing Facile Detection of Antibiotics Using Gold Nanoparticle Assays

[Image: see text] We have used systematic evolution of ligands by exponential enrichment (SELEX) to isolate RNA aptamers against aminoglycoside antibiotics. The SELEX rounds were toggled against four pairs of aminoglycosides with the goal of isolating reagents that recognize conserved structural fea...

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Detalhes bibliográficos
Main Authors: Derbyshire, Nicola, White, Simon J., Bunka, David H. J., Song, Lei, Stead, Sara, Tarbin, Jonathan, Sharman, Matthew, Zhou, Dejian, Stockley, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413241/
https://ncbi.nlm.nih.gov/pubmed/22793869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac300815c
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