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Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment
It is a challenge to evaluate experimental treatments where it is suspected that the treatment effect may only be strong for certain subpopulations, such as those having a high initial severity of disease, or those having a particular gene variant. Standard randomized controlled trials can have low...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413180/ https://ncbi.nlm.nih.gov/pubmed/23049131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biomet/asr055 |
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