The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability

Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all of which are important in preserving genome stability. Three of these, BLM, WRN and RECQL4, are mutated in human diseases manifesting in premature aging and cancer. We are interested in determining t...

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Autors principals: Singh, Dharmendra Kumar, Popuri, Venkateswarlu, Kulikowicz, Tomasz, Shevelev, Igor, Ghosh, Avik K., Ramamoorthy, Mahesh, Rossi, Marie L., Janscak, Pavel, Croteau, Deborah L., Bohr, Vilhelm A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413146/
https://ncbi.nlm.nih.gov/pubmed/22544709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks349
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