A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts

miR-21 is the most commonly over-expressed microRNA (miRNA) in cancer and a proven oncogene. Hsa-miR-21 is located on chromosome 17q23.2, immediately downstream of the vacuole membrane protein-1 (VMP1) gene, also known as TMEM49. VMP1 transcripts initiate ∼130 kb upstream of miR-21, are spliced, and...

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Bibliografiske detaljer
Main Authors: Ribas, Judit, Ni, Xiaohua, Castanares, Mark, Liu, Minzhi M., Esopi, David, Yegnasubramanian, Srinivasan, Rodriguez, Ronald, Mendell, Joshua T., Lupold, Shawn E.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413119/
https://ncbi.nlm.nih.gov/pubmed/22505577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks308
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