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A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts
miR-21 is the most commonly over-expressed microRNA (miRNA) in cancer and a proven oncogene. Hsa-miR-21 is located on chromosome 17q23.2, immediately downstream of the vacuole membrane protein-1 (VMP1) gene, also known as TMEM49. VMP1 transcripts initiate ∼130 kb upstream of miR-21, are spliced, and...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413119/ https://ncbi.nlm.nih.gov/pubmed/22505577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks308 |
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