Structural mechanisms of the degenerate sequence recognition by Bse634I restriction endonuclease

Restriction endonuclease Bse634I recognizes and cleaves the degenerate DNA sequence 5′-R/CCGGY-3′ (R stands for A or G; Y for T or C, ‘/’ indicates a cleavage position). Here, we report the crystal structures of the Bse634I R226A mutant complexed with cognate oligoduplexes containing ACCGGT and GCCG...

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Main Authors: Manakova, Elena, Gražulis, Saulius, Zaremba, Mindaugas, Tamulaitiene, Giedre, Golovenko, Dmitrij, Siksnys, Virginijus
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
Assuntos:
Nucleic Acid Enzymes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413111/
https://ncbi.nlm.nih.gov/pubmed/22495930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks300
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