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Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells
Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) are both capable of self-renewal, with HSCs sustaining multiple blood lineage differentiation and LSCs indefinitely propagating leukemia. The GABP complex, consisting of DNA binding GABPβ subunit and transactivation GABPβ subunit, critic...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413094/ https://ncbi.nlm.nih.gov/pubmed/22862946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.05.021 |
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