Thyroidectomy with neoadjuvant PLX4720 extends survival and decreases tumor burden in an orthotopic mouse model of anaplastic thyroid cancer

BACKGROUND: B-Raf(V600E) is a frequent mutation in anaplastic thyroid cancers and is a novel therapeutic target. We hypothesized that PLX4720 (an inhibitor of B-Raf(V600E)) and thyroidectomy would extend survival and decrease tumor burden in a mouse model. METHODS: Orthotopic anaplastic thyroid tumo...

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Main Authors: Nehs, Matthew A., Nagarkatti, Sushruta, Nucera, Carmelo, Hodin, Richard A., Parangi, Sareh
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413092/
https://ncbi.nlm.nih.gov/pubmed/21134546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2010.09.001
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