Eltrombopag, a thrombopoietin receptor agonist, enhances human umbilical cord blood hematopoietic stem/primitive progenitor cell expansion and promotes multi-lineage hematopoiesis

Umbilical cord blood (UCB) transplantation has emerged as promising therapy, but is challenged by scarcity of stem cells. Eltrombopag is a non-peptide, thrombopoietin (TPO) receptor agonist, which selectively activates c-Mpl in humans and chimpanzees. We investigated eltrombopag’s effects on human U...

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Hlavní autoři: Sun, Hongliang, Tsai, Ying, Nowak, Irena, Liesveld, Jane, Chen, Yuhchyau
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412938/
https://ncbi.nlm.nih.gov/pubmed/22683680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2012.05.001
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