COMMD1-Deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis

New therapeutic concepts developed in rodent models should ideally be evaluated in large animal models prior to human clinical application. COMMD1-deficiency in dogs leads to hepatic copper accumulation and chronic hepatitis representing a Wilson’s disease like phenotype. Detailed understanding of t...

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Main Authors: Favier, Robert P., Spee, Bart, Schotanus, Baukje A., van den Ingh, Ted S. G. A. M., Fieten, Hille, Brinkhof, Bas, Viebahn, Cornelia S., Penning, Louis C., Rothuizen, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412840/
https://ncbi.nlm.nih.gov/pubmed/22879914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042158
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