Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model

BACKGROUND: Spinocerebellar ataxia type 7 (SCA7) is one of nine inherited neurodegenerative disorders caused by polyglutamine (polyQ) expansions. Common mechanisms of disease pathogenesis suggested for polyQ disorders include aggregation of the polyQ protein and induction of oxidative stress. Howeve...

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Bibliografiske detaljer
Main Authors: Ajayi, Abiodun, Yu, Xin, Lindberg, Staffan, Langel, Ülo, Ström, Anna-Lena
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412756/
https://ncbi.nlm.nih.gov/pubmed/22827889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-13-86
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