Attenuated Salmonella typhimurium delivering DNA vaccine encoding duck enteritis virus UL24 induced systemic and mucosal immune responses and conferred good protection against challenge

Orally delivered DNA vaccines against duck enteritis virus (DEV) were developed using live attenuated Salmonella typhimurium (SL7207) as a carrier and Escherichia coli heat labile enterotoxin B subunit (LTB) as a mucosal adjuvant. DNA vaccine plasmids pVAX-UL24 and pVAX-LTB-UL24 were constructed and...

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Detalhes bibliográficos
Main Authors: Yu, Xia, Jia, Renyong, Huang, Juan, Shu, Bin, Zhu, Dekang, Liu, Qing, Gao, Xinghong, Lin, Meng, Yin, Zhongqiong, Wang, Mingshu, Chen, Shun, Wang, Yin, Chen, Xiaoyue, Cheng, Anchun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412168/
https://ncbi.nlm.nih.gov/pubmed/22770566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1297-9716-43-56
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