HRT, Herbal Formula, Induces G(2)/M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells

We have demonstrated the anticancer effect of HRT in HCT116, human colon carcinoma cells. HRT inhibited cancer cell growth by causing cell cycle arrest at G(2)/M and inducing apoptosis as evidenced by DNA fragmentation assay. We found that HRT induces the activation of caspase-3, -8, and -9, whereas...

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Detalhes bibliográficos
Main Authors: Yim, Nam-Hui, Cho, Won-Kyung, Lee, Ju Hye, Jung, Young Pil, Yang, Hye Jin, Ma, Jin Yeul
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412102/
https://ncbi.nlm.nih.gov/pubmed/22899960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/871893
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