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HRT, Herbal Formula, Induces G(2)/M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells

We have demonstrated the anticancer effect of HRT in HCT116, human colon carcinoma cells. HRT inhibited cancer cell growth by causing cell cycle arrest at G(2)/M and inducing apoptosis as evidenced by DNA fragmentation assay. We found that HRT induces the activation of caspase-3, -8, and -9, whereas...

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Autors principals: Yim, Nam-Hui, Cho, Won-Kyung, Lee, Ju Hye, Jung, Young Pil, Yang, Hye Jin, Ma, Jin Yeul
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412102/
https://ncbi.nlm.nih.gov/pubmed/22899960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/871893
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