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Nanoparticle-based artificial RNA silencing machinery for antiviral therapy

RNA interference is a fundamental gene regulatory mechanism that is mediated by the RNA-induced silencing complex (RISC). Here we report that an artificial nanoparticle complex can effectively mimic the function of the cellular RISC machinery for inducing target RNA cleavage. Our results show that a...

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Bibliografiske detaljer
Main Authors: Wang, Zhongliang, Liu, Hongyan, Yang, Soon Hye, Wang, Tie, Liu, Chen, Cao, Y. Charles
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412013/
https://ncbi.nlm.nih.gov/pubmed/22802676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207766109
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