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Nanoparticle-based artificial RNA silencing machinery for antiviral therapy

RNA interference is a fundamental gene regulatory mechanism that is mediated by the RNA-induced silencing complex (RISC). Here we report that an artificial nanoparticle complex can effectively mimic the function of the cellular RISC machinery for inducing target RNA cleavage. Our results show that a...

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Detalhes bibliográficos
Main Authors: Wang, Zhongliang, Liu, Hongyan, Yang, Soon Hye, Wang, Tie, Liu, Chen, Cao, Y. Charles
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412013/
https://ncbi.nlm.nih.gov/pubmed/22802676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207766109
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