Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1

Collagenases of the matrix metalloproteinase (MMP) family play major roles in morphogenesis, tissue repair, and human diseases, but how they recognize and cleave the collagen triple helix is not fully understood. Here, we report temperature-dependent binding of a catalytically inactive MMP-1 mutant...

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Detalhes bibliográficos
Main Authors: Manka, Szymon W., Carafoli, Federico, Visse, Robert, Bihan, Dominique, Raynal, Nicolas, Farndale, Richard W., Murphy, Gillian, Enghild, Jan J., Hohenester, Erhard, Nagase, Hideaki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411981/
https://ncbi.nlm.nih.gov/pubmed/22761315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204991109
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