Lipocalin 2 Deficiency Dysregulates Iron Homeostasis and Exacerbates Endotoxin-Induced Sepsis

Various states of inflammation, including sepsis, are associated with hypoferremia, which limits iron availability to pathogens and reduces iron-mediated oxidative stress. Lipocalin 2 (siderocalin, 24p3) plays a central role in iron transport. Accordingly, Lipocalin 2-deficient mice (Lcn2KO) exhibit...

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Autores principales: Srinivasan, Gayathri, Aitken, Jesse D, Zhang, Benyue, Carvalho, Frederic A, Chassaing, Benoit, Shashidharamurthy, Rangaiah, Borregaard, Niels, Jones, Dean P, Gewirtz, Andrew T, Vijay-Kumar, Matam
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411903/
https://ncbi.nlm.nih.gov/pubmed/22786765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200892
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