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DYT1 Knock-In Mice Are Not Sensitized against Mitochondrial Complex-II Inhibition
DYT1 is caused by a partly penetrant dominant mutation in TOR1A that leads to a glutamic acid deletion (ΔE) in torsinA. Identifying environmental factors that modulate disease pathogenesis and penetrance could help design therapeutic strategies for dystonia. Several cell-based studies suggest that e...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411799/ https://ncbi.nlm.nih.gov/pubmed/22880064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042644 |
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