Rapid Detection of an ABT-737-Sensitive Primed for Death State in Cells Using Microplate-Based Respirometry

Cells that exhibit an absolute dependence on the anti-apoptotic BCL-2 protein for survival are termed “primed for death” and are killed by the BCL-2 antagonist ABT-737. Many cancers exhibit a primed phenotype, including some that are resistant to conventional chemotherapy due to high BCL-2 expressio...

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Main Authors: Clerc, Pascaline, Carey, Gregory B., Mehrabian, Zara, Wei, Michael, Hwang, Hyehyun, Girnun, Geoffrey D., Chen, Hegang, Martin, Stuart S., Polster, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411749/
https://ncbi.nlm.nih.gov/pubmed/22880001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042487
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