Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: a possible defense against transforming growth factor-β mediated fibrosis

BACKGROUND: Mechanical overload of the heart is associated with excessive deposition of extracellular matrix proteins and the development of cardiac fibrosis. This can result in reduced ventricular compliance, diastolic dysfunction, and heart failure. Extracellular matrix synthesis is regulated prim...

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Hlavní autoři: Watson, Chris J, Phelan, Dermot, Xu, Maojia, Collier, Patrick, Neary, Roisin, Smolenski, Albert, Ledwidge, Mark, McDonald, Kenneth, Baugh, John
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411484/
https://ncbi.nlm.nih.gov/pubmed/22768849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-1536-5-9
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