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PKCε Promotes Cardiac Mitochondrial and Metabolic Adaptation to Chronic Hypobaric Hypoxia by GSK3β Inhibition

PKCε is central to cardioprotection. Sub-proteome analysis demonstrated co-localization of activated cardiac PKCε (aPKCε) with metabolic, mitochondrial, and cardioprotective modulators like hypoxia-inducible factor 1α (HIF-1α). aPKCε relocates to the mitochondrion, inactivating glycogen synthase kin...

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Xehetasun bibliografikoak
Egile Nagusiak: McCarthy, Joy, Lochner, Amanda, Opie, Lionel H., Sack, Michael N., Essop, M. Faadiel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411281/
https://ncbi.nlm.nih.gov/pubmed/21660969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22592
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