Vascular Endothelial Cell-specific MicroRNA-15a Inhibits Angiogenesis in Hindlimb Ischemia

The effects and potential mechanisms of the vascular endothelial cell (EC)-enriched microRNA-15a (miR-15a) on angiogenesis remain unclear. Here, we show a novel finding that EC-selective miR-15a transgenic overexpression leads to reduced blood vessel formation and local blood flow perfusion in mouse...

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Bibliografiske detaljer
Main Authors: Yin, Ke-Jie, Olsen, Karl, Hamblin, Milton, Zhang, Jifeng, Schwendeman, Steven P., Chen, Y. Eugene
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411046/
https://ncbi.nlm.nih.gov/pubmed/22692216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.364414
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