6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment

κ-Opioid receptor (KOR) agonists do not activate the reward pathway stimulated by morphine-like μ-opioid receptor (MOR) agonists and thus have been considered to be promising nonaddictive analgesics. However, KOR agonists produce other adverse effects, including dysphoria, diuresis, and constipation...

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Bibliographic Details
Main Authors: Rives, Marie-Laure, Rossillo, Mary, Liu-Chen, Lee-Yuan, Javitch, Jonathan A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
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Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411045/
https://ncbi.nlm.nih.gov/pubmed/22736766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.387332
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