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Coordinated Regulation of Transcription Factor Bcl11b Activity in Thymocytes by the Mitogen-activated Protein Kinase (MAPK) Pathways and Protein Sumoylation

The transcriptional regulatory protein Bcl11b is essential for T-cell development. We have discovered a dynamic, MAPK-regulated pathway involving sequential, linked, and reversible post-translational modifications of Bcl11b in thymocytes. MAPK-mediated phosphorylation of Bcl11b was coupled to its ra...

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Bibliografiske detaljer
Main Authors: Zhang, Ling-juan, Vogel, Walter K., Liu, Xiao, Topark-Ngarm, Acharawan, Arbogast, Brian L., Maier, Claudia S., Filtz, Theresa M., Leid, Mark
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411033/
https://ncbi.nlm.nih.gov/pubmed/22700985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.344176
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