Transforming Growth Factor-β/SMAD Target Gene SKIL Is Negatively Regulated by the Transcriptional Cofactor Complex SNON-SMAD4

The human SKI-like (SKIL) gene encodes the SMAD transcriptional corepressor SNON that antagonizes TGF-β signaling. SNON protein levels are tightly regulated by the TGF-β pathway: whereas a short stimulation with TGF-β decreases SNON levels by its degradation via the proteasome, longer TGF-β treatmen...

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Main Authors: Tecalco-Cruz, Angeles C., Sosa-Garrocho, Marcela, Vázquez-Victorio, Genaro, Ortiz-García, Layla, Domínguez-Hüttinger, Elisa, Macías-Silva, Marina
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411014/
https://ncbi.nlm.nih.gov/pubmed/22674574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.386599
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