IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma

BACKGROUND: Ocular hypertension is a major risk factor for glaucoma, a neurodegenerative disease characterized by an irreversible decrease in ganglion cells and their axons. Macroglial and microglial cells appear to play an important role in the pathogenic mechanisms of the disease. Here, we study t...

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Hauptverfasser: Gallego, Beatriz I, Salazar, Juan J, de Hoz, Rosa, Rojas, Blanca, Ramírez, Ana I, Salinas-Navarro, Manuel, Ortín-Martínez, Arturo, Valiente-Soriano, Francisco J, Avilés-Trigueros, Marcelino, Villegas-Perez, Maria P, Vidal-Sanz, Manuel, Triviño, Alberto, Ramírez, Jose M
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410794/
https://ncbi.nlm.nih.gov/pubmed/22583833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-92
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