Genotype Imputation of Metabochip SNPs Using a Study-Specific Reference Panel of ~4,000 Haplotypes in African Americans From the Women’s Health Initiative

Genetic imputation has become standard practice in modern genetic studies. However, several important issues have not been adequately addressed including the utility of study-specific reference, performance in admixed populations, and quality for less common (minor allele frequency [MAF] 0.005–0.05)...

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Detalhes bibliográficos
Main Authors: Liu, Eric Yi, Buyske, Steven, Aragaki, Aaron K., Peters, Ulrike, Boerwinkle, Eric, Carlson, Chris, Carty, Cara, Crawford, Dana C., Haessler, Jeff, Hindorff, Lucia A., Marchand, Loic Le, Manolio, Teri A., Matise, Tara, Wang, Wei, Kooperberg, Charles, North, Kari E., Li, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410659/
https://ncbi.nlm.nih.gov/pubmed/22851474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21603
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