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A Novel Point Mutation in the KCNJ5 Gene Causing Primary Hyperaldosteronism and Early-Onset Autosomal Dominant Hypertension

CONTEXT: Aldosterone production in the adrenal zona glomerulosa is mainly regulated by angiotensin II, [K(+)], and ACTH. Genetic deletion of subunits of K(+)-selective leak (KCNK) channels TWIK-related acid sensitive K(+)-1 and/or TWIK-related acid sensitive K(+)-3 in mice results in primary hyperal...

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Detalhes bibliográficos
Main Authors:	Charmandari, Evangelia, Sertedaki, Amalia, Kino, Tomoshige, Merakou, Christina, Hoffman, Dax A., Hatch, Michael M., Hurt, Darrell E., Lin, Lin, Xekouki, Paraskevi, Stratakis, Constantine A., Chrousos, George P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Endocrine Society 2012
Assuntos:	JCEM Online: Advances in Genetics
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3410272/ https://ncbi.nlm.nih.gov/pubmed/22628607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-1334
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A Novel Point Mutation in the KCNJ5 Gene Causing Primary Hyperaldosteronism and Early-Onset Autosomal Dominant Hypertension

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