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Gla-domainless factor Xa: molecular bait to bypass a blocked tenase complex

BACKGROUND: Hemophilia is caused by deficiencies in coagulation factor VIII or IX, resulting in direct blockade of the intrinsic tenase complex and indirect blockade of the extrinsic tenase complex which is rapidly inhibited upon binding of factor Xa to tissue factor pathway inhibitor. We evaluated...

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Hlavní autoři: Marlu, Raphaël, Polack, Benoît
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409813/
https://ncbi.nlm.nih.gov/pubmed/22491732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.055699
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