Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats

1. The pharmacokinetics(PK) (absorption, distribution, metabolism, excretion) of peginesatide.a synthetic, PEGylated, investigational, peptide-based erythropoiesis-stimulating agent (ESA), was evaluated in rats. The PK profile was evaluated at 0.1-5 mg·kg(−1) IV using unlabeled or [(14)C]-labeled pe...

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Bibliographic Details
Main Authors: Woodburn, Kathryn W., Holmes, Christopher P., Wilson, Susan D., Fong, Kei-Lai, Press, Randall J., Moriya, Yuu, Tagawa, Yoshihiko
Format: Artigo
Language:Inglês
Published: Informa Healthcare 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409459/
https://ncbi.nlm.nih.gov/pubmed/22188389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2011.649310
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