Genome-wide genetic variations are highly correlated with proximal DNA methylation patterns

5-methyl-cytosines at CpG sites frequently mutate into thymines, accounting for a large proportion of spontaneous point mutations. The repair system would leave substantial numbers of errors in neighboring regions if the synthesis of erased gaps around deaminated 5-methyl-cytosines is error-prone. I...

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Autors principals: Qu, Wei, Hashimoto, Shin-ichi, Shimada, Atsuko, Nakatani, Yoichiro, Ichikawa, Kazuki, Saito, Taro L., Ogoshi, Katsumi, Matsushima, Kouji, Suzuki, Yutaka, Sugano, Sumio, Takeda, Hiroyuki, Morishita, Shinichi
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409255/
https://ncbi.nlm.nih.gov/pubmed/22689467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.140236.112
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