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Novobiocin interferes with the binding of transcription factors TFIIIA and TFIIIC to the promoters of class III genes.
Novobiocin has been shown to inhibit class III gene transcription from both chromatin and non-chromatin templates. Since novobiocin is a well characterized inhibitor of type II DNA topoisomerases, it has been postulated that a gyrase activity is necessary for transcription. Using DNase I footprintin...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1987
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC340867/ https://ncbi.nlm.nih.gov/pubmed/3588299 |
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