HLA-DPβ1 Asp84-Lys69 antigen-binding signature predicts event-free survival in childhood B-cell precursor acute lymphoblastic leukaemia: results from the MRC UKALL XI childhood ALL trial

We previously reported that children in the UKALL XI ALL trial with HLA-DP 1 and -DP 3 supertypes had significantly worse event-free survival (EFS) than children with other DP supertypes. As DP 1 and DP 3 share two of four key antigen-binding amino-acid polymorphisms (aspartic acid84–lysine69), we a...

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Detalhes bibliográficos
Main Authors: Taylor, G M, Wade, R, Hussain, A, Thompson, P, Hann, I, Gibson, B, Eden, T, Richards, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408639/
https://ncbi.nlm.nih.gov/pubmed/22852049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2012.25
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