Nanoparticle-Mediated Local Delivery of an Antisense TGF-β1 Construct Inhibits Intimal Hyperplasia in Autogenous Vein Grafts in Rats

BACKGROUND: Intimal hyperplasia is one of the most important causes of vascular graft failure. Numerous studies have correlated transforming growth factor-β1 (TGF-β1) with extracellular matrix (ECM) deposition, a hallmark of intimal thickening. PRINCIPAL FINDINGS: In the present study, we performed...

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Dettagli Bibliografici
Autori principali: Sun, Da-Xin, Liu, Zhen, Tan, Xiao-Dong, Cui, Dong-Xu, Wang, Bao-Sheng, Dai, Xian-Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408488/
https://ncbi.nlm.nih.gov/pubmed/22860019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041857
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