Pancreatic Duodenal Homeobox Protein 1 (Pdx1) Is a Novel β-Cell Specific Autoantigen for Type 1 Diabetes

Pdx1 is a key transcription factor involved in the regulation of insulin gene expression that is expressed at high levels in the β-cells of the pancreatic islets. We asked whether Pdx1 is a target of anti-islet autoimmunity in Type 1 diabetes (T1D). Pdx1 autoantibodies (PAA) were detected in non-obe...

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Main Authors: Li, Shi-Wu, Koya, Vijay, Li, Yi, Donelan, William, Lin, Peng, Reeves, Westley H., Yang, Li-Jun
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408089/
https://ncbi.nlm.nih.gov/pubmed/19901909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2009.116
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