Evolution of Siglec-11 and Siglec-16 Genes in Hominins

We previously reported a human-specific gene conversion of SIGLEC11 by an adjacent paralogous pseudogene (SIGLEC16P), generating a uniquely human form of the Siglec-11 protein, which is expressed in the human brain. Here, we show that Siglec-11 is expressed exclusively in microglia in all human brai...

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Main Authors: Wang, Xiaoxia, Mitra, Nivedita, Cruz, Pedro, Deng, Liwen, Varki, Nissi, Angata, Takashi, Green, Eric D., Mullikin, Jim, Hayakawa, Toshiyuki, Varki, Ajit
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408085/
https://ncbi.nlm.nih.gov/pubmed/22383531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mss077
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