Echinacea Purpurea Significantly Induces Cytochrome P450 3A (CYP3A) but does not alter Lopinavir-Ritonavir Exposure in Healthy Subjects

STUDY OBJECTIVE: To determine the influence of Echinacea purpurea on the pharmacokinetics of lopinavir-ritonavir, and on CYP3A and P-glycoprotein (P-gp) activity using the probe substrates midazolam, and fexofenadine, respectively. DESIGN: Open label, single-sequence pharmacokinetic study. SETTING:...

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Autors principals: Penzak, Scott R., Robertson, Sarah M., Hunt, Jennifer D., Chairez, Cheryl, Malati, Christine Y., Alfaro, Raul M., Stevenson, James M., Candidate, Pharm.D., Kovacs, Joseph A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407958/
https://ncbi.nlm.nih.gov/pubmed/20653355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1592/phco.30.8.797
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