Osmotic Stress, not Aldose Reductase Activity, Directly induces Growth Factors and MAPK Signaling changes during Sugar Cataract Formation

In sugar cataract formation in rats, aldose reductase (AR) actitvity is not only linked to lenticular sorbitol (diabetic) or galactitol (galactosemic) formation but also to signal transduction changes, cytotoxic signals and activation of apoptosis. Using both in vitro and in vivo techniques, the int...

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Bibliographic Details
Main Authors: Zhang, Peng, Xing, Kuiyi, Randazzo, James, Blessing, Karen, Lou, Marjorie F., Kador, Peter F.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407318/
https://ncbi.nlm.nih.gov/pubmed/22710095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2012.05.007
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