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Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase

Isocitrate dehydrogenase 1 (IDH1), a cytosolic enzyme that converts isocitrate to alpha‐ketoglutarate, has been shown to be dysregulated during tumorigenesis. However, at what stage of cancer development IDH1 is dysregulated and how IDH1 may affect cell transformation and tumor promotion during earl...

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Détails bibliographiques
Auteurs principaux: Robbins, Delira, Wittwer, Jennifer A., Codarin, Sarah, Circu, Magdalena L., Aw, Tak Yee, Huang, Ting‐Ting, Van Remmen, Holly, Richardson, Arlan, Wang, David B., Witt, Stephan N., Klein, Ronald L., Zhao, Yunfeng
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407305/
https://ncbi.nlm.nih.gov/pubmed/22533343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02317.x
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