Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase

Isocitrate dehydrogenase 1 (IDH1), a cytosolic enzyme that converts isocitrate to alpha‐ketoglutarate, has been shown to be dysregulated during tumorigenesis. However, at what stage of cancer development IDH1 is dysregulated and how IDH1 may affect cell transformation and tumor promotion during earl...

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Главные авторы: Robbins, Delira, Wittwer, Jennifer A., Codarin, Sarah, Circu, Magdalena L., Aw, Tak Yee, Huang, Ting‐Ting, Van Remmen, Holly, Richardson, Arlan, Wang, David B., Witt, Stephan N., Klein, Ronald L., Zhao, Yunfeng
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2012
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407305/
https://ncbi.nlm.nih.gov/pubmed/22533343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02317.x
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