An N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirooxindole Lactones

A cooperative catalysis approach for the enantioselective formal [3+2] addition of α,β-unsaturated aldehydes to isatins has been developed. The N-heterocyclic carbene (NHC)-catalyzed homoenolate annulations of β-aryl enals require the addition of lithium chloride for high levels of enantioselectivit...

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Main Authors: Dugal-Tessier, Julien, O’Bryan, Elizabeth A., Schroeder, Thomas B. H., Cohen, Daniel T., Scheidt, Karl A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406933/
https://ncbi.nlm.nih.gov/pubmed/22489096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201201643
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