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Expression reduction in mammalian X chromosome evolution refutes Ohno’s hypothesis of dosage compensation
Susumu Ohno proposed in 1967 that, during the origin of mammalian sex chromosomes from a pair of autosomes, per-allele expression levels of X-linked genes were doubled to compensate for the degeneration of their Y homologs. This conjecture forms the foundation of the current evolutionary model of se...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406839/ https://ncbi.nlm.nih.gov/pubmed/22753487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201816109 |
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