Transient opening of the perineurial barrier for analgesic drug delivery

Selective targeting of sensory or nociceptive neurons in peripheral nerves remains a clinically desirable goal. Delivery of promising analgesic drugs is often impeded by the perineurium, which functions as a diffusion barrier attributable to tight junctions. We used perineurial injection of hyperton...

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Detalhes bibliográficos
Main Authors: Hackel, Dagmar, Krug, Susanne M., Sauer, Reine-Solange, Mousa, Shaaban A., Böcker, Alexander, Pflücke, Diana, Wrede, Esther-Johanna, Kistner, Katrin, Hoffmann, Tali, Niedermirtl, Benedikt, Sommer, Claudia, Bloch, Laura, Huber, Otmar, Blasig, Ingolf E., Amasheh, Salah, Reeh, Peter W., Fromm, Michael, Brack, Alexander, Rittner, Heike L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406837/
https://ncbi.nlm.nih.gov/pubmed/22733753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120800109
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