Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells

Glucocorticoids (GCs) are common components of many chemotherapeutic regimens for lymphoid malignancies. GC-induced apoptosis involves an intrinsic mitochondria-dependent pathway. BIM (BCL-2-interacting mediator of cell death), a BCL-2 homology 3-only pro-apoptotic protein, is upregulated by dexamet...

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Detalhes bibliográficos
Main Authors: Heidari, N, Miller, A V, Hicks, M A, Marking, C B, Harada, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406588/
https://ncbi.nlm.nih.gov/pubmed/22825467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.89
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