Microfibrous substrate geometry as a critical trigger for organization, self-renewal, and differentiation of human embryonic stem cells within synthetic 3-dimensional microenvironments

Substrates used to culture human embryonic stem cells (hESCs) are typically 2-dimensional (2-D) in nature, with limited ability to recapitulate in vivo-like 3-dimensional (3-D) microenvironments. We examined critical determinants of hESC self-renewal in poly-d-lysine-pretreated synthetic polymer-bas...

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Detalhes bibliográficos
Main Authors: Carlson, Aaron L., Florek, Charles A., Kim, Joseph J., Neubauer, Thomas, Moore, Jennifer C., Cohen, Rick I., Kohn, Joachim, Grumet, Martin, Moghe, Prabhas V.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405262/
https://ncbi.nlm.nih.gov/pubmed/22542683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-192732
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