Treatment of adult MPSI mouse brains with IDUA-expressing mesenchymal stem cells decreases GAG deposition and improves exploratory behavior

BACKGROUND: Mucopolysaccharidosis type I (MPSI) is caused by a deficiency in alpha-L iduronidase (IDUA), which leads to lysosomal accumulation of the glycosaminoglycans (GAGs) dermatan and heparan sulfate. While the currently available therapies have good systemic effects, they only minimally affect...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: da Silva, Flávia Helena, Pereira, Vanessa Gonçalves, Yasumura, Eduardo G, Tenório, Lígia Zacchi, de Carvalho, Leonardo Pinto, Lisboa, Bianca Cristina Garcia, Matsumoto, Priscila Keiko, Stilhano, Roberta Sessa, Samoto, Vivian Y, Calegare, Bruno Frederico Aguilar, Brandão, Letícia de Campos, D’Almeida, Vânia, Filippo, Thaís RM, Porcionatto, Marimélia, Toma, Leny, Nader, Helena Bonciani, Valero, Valderez Bastos, Camassola, Melissa, Nardi, Nance Beyer, Han, Sang Won
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2012
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404940/
https://ncbi.nlm.nih.gov/pubmed/22520214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-0556-10-2
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы