Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia

Intermittent hypoxia (IH) and sleep fragmentation (SF) are major manifestations of sleep apnea, a frequent condition in aging humans. Sleep perturbations are frequent in Alzheimer's disease (AD) and may underlie the progression of disease. We hypothesized that acute short-term IH, SF, and their...

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Hlavní autoři: Kaushal, Navita, Ramesh, Vijay, Gozal, David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
Translational Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404642/
https://ncbi.nlm.nih.gov/pubmed/22573105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00025.2012
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