The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae

DFNA5 was first identified as a gene responsible for autosomal dominant deafness. Different mutations were found, but they all resulted in exon 8 skipping during splicing and premature termination of the protein. Later, it became clear that the protein also has a tumor suppression function and that...

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Bibliografiske detaljer
Main Authors: Van Rossom, Sofie, Op de Beeck, Ken, Franssens, Vanessa, Swinnen, Erwin, Schepers, Anne, Ghillebert, Ruben, Caldara, Marina, Van Camp, Guy, Winderickx, Joris
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2012
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404532/
https://ncbi.nlm.nih.gov/pubmed/22848872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00077
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