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Neuropeptidase activity is down-regulated by estradiol in steroid-sensitive regions of the hypothalamus in female mice
Thimet oligopeptidase (TOP) and prolyl endopeptidase (PEP) are neuropeptidases involved in the hydrolysis of gonadotropin-releasing hormone, a key component of the hypothalamic-pituitary-gonadal axis. GnRH is regulated in part by feedback from steroid hormones such as estradiol. Previously, we demon...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3404208/ https://ncbi.nlm.nih.gov/pubmed/22672888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.npep.2012.04.002 |
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