Oxidative Stress-Induced Glomerular Mineralocorticoid Receptor Activation Limits the Benefit of Salt Reduction in Dahl Salt-Sensitive Rats

BACKGROUND: Mineralocorticoid receptor (MR) antagonists attenuate renal injury in salt-sensitive hypertensive rats with low plasma aldosterone levels. We hypothesized that oxidative stress causes MR activation in high-salt-fed Dahl salt-sensitive rats. Furthermore, we determined if MR activation per...

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Main Authors: Kitada, Kento, Nakano, Daisuke, Liu, Ya, Fujisawa, Yoshihide, Hitomi, Hirofumi, Shibayama, Yuki, Shibata, Hirotaka, Nagai, Yukiko, Mori, Hirohito, Masaki, Tsutomu, Kobori, Hiroyuki, Nishiyama, Akira
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404044/
https://ncbi.nlm.nih.gov/pubmed/22911865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041896
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