Aldolase B Knockdown Prevents High Glucose-Induced Methylglyoxal Overproduction and Cellular Dysfunction in Endothelial Cells

We used cultured endothelial cells as a model to examine whether up-regulation of aldolase B and enhanced methylglyoxal (MG) formation play an important role in high glucose-induced overproduction of advanced glycosylation endproducts (AGEs), oxidative stress and cellular dysfunction. High glucose (...

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Main Authors: Liu, Jianghai, Mak, Timothy Chun-Ping, Banigesh, Ali, Desai, Kaushik, Wang, Rui, Wu, Lingyun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404030/
https://ncbi.nlm.nih.gov/pubmed/22911800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041495
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