Periostin Facilitates Skin Sclerosis via PI3K/Akt Dependent Mechanism in a Mouse Model of Scleroderma

OBJECTIVE: Periostin, a novel matricellular protein, is recently reported to play a crucial role in tissue remodeling and is highly expressed under fibrotic conditions. This study was undertaken to assess the role of periostin in scleroderma. METHODS: Using skin from patients and healthy donors, the...

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Detalhes bibliográficos
Main Authors: Yang, Lingli, Serada, Satoshi, Fujimoto, Minoru, Terao, Mika, Kotobuki, Yorihisa, Kitaba, Shun, Matsui, Saki, Kudo, Akira, Naka, Tetsuji, Murota, Hiroyuki, Katayama, Ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404023/
https://ncbi.nlm.nih.gov/pubmed/22911870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041994
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